What are the benefits of CBD?
CBD can be taken daily for cell regeneration and overall health. Cannabis-derived cannabidiol (CBD) oil is a cannabis-derived product. It's a cannabinoid, which are substances found in marijuana plants naturally. CBD does not produce a “high” or any type of intoxication, despite the fact that it comes from marijuana plants; THC is the cannabinoid that does.
Because of recreational marijuana use, there is some debate around cannabis products like CBD oil. However, people are becoming more aware of the potential health benefits of CBD oil.
Here's a top 20 count down of important points you need to know about the above potential CBD medical applications and the current state of research so you can make informed decisions:20 Anxiety
CBD may be able to assist you in overcoming anxiety. It may alter the way your brain's receptors respond to serotonin, a neurotransmitter connected to mental wellness, according to researchers. Receptors are little proteins connected to the surface of your cells that receive chemical messages and help your cells respond to various stimuli.
A 600mg dose of CBD was proven to help patients with social anxiety give a speech in one study.
A four-minute lecture with little time to prepare might be exhausting for students with generalized social anxiety. In a simulated public speaking test, a small study published in the journal Neuropsychopharmacology reported that CBD seemed to improve uneasiness and cognitive impairment in patients with social anxiety.
In contrast to the placebo group, healthy volunteers who were given CBD exhibited little to no change in their emotional response to unpleasant images or phrases in a double-blind research. “If it's a calming medicine, it should affect their responses to the stimuli,” said Harriet de Wit, co-author of the study and professor of psychiatry and behavioral neuroscience at the University of Chicago. “However, it did not.”19 Post-Traumatic Stress Disorder (PTSD)
CBD has also been demonstrated in animal tests to help with anxiety relief by reducing stress and decreasing physiological symptoms of anxiety, such as an increased heart rate.
alleviating post-traumatic stress disorder (PTSD) symptoms and inducing sleep in insomnia cases.
Many troops return home plagued by combat and PTSD, and they frequently avoid activities, locations, or people who remind them of their traumatic experiences. The Veterans Affairs Department is supporting the first CBD trial, which will combine CBD with psychotherapy.
The study's primary investigator, Mallory Loflin, an assistant adjunct professor at the University of California, San Diego, said, "Our top therapies try to disrupt the relationship between recollections of the trauma and the fear response." “We believe that CBD, at least in animal models, can help speed up that process.” Despite the fact that massive clinical trials are currently ongoing, psychologists say there isn't enough data to suggest that this is a viable treatment.18 Anti-seizure & Epilepsy Medication
CBD has previously been mentioned as a viable epilepsy therapy. The research is still in its infancy. Researchers are examining how much CBD can help people with epilepsy lessen the frequency of seizures they have, as well as how safe it is. Cannabidiol research, according to the American Epilepsy Society, gives promise for seizure disorders, and study is now being undertaken to better understand safe use.
In 2016, 214 persons with epilepsy participated in a study. The trial participants supplemented their anti-epilepsy drugs with oral doses of CBD ranging from 2 to 5 mg per day. The individuals were studied for 12 weeks by the study's researchers, who kept track of any undesirable side effects and the frequency of their seizures. Participants had 36.5 percent fewer seizures per month on average. However, 12 percent of the patients experienced serious side effects.17 Neuroprotective properties
Researchers are studying a receptor in the brain to see if CBD can benefit people with neurodegenerative diseases, which are diseases that cause the brain and nerves to degenerate over time. CB1 is the name of this receptor.
Researchers are investigating the use of CBD oil to treat:
● Alzheimer's illness
● Parkinson's disease
● Multiple sclerosis (MS)
● Stroke caused by Parkinson's disease
● CBD oil may also help to reduce inflammation, which can exacerbate neurological symptoms.
To fully comprehend the impact of CBD oil on neurodegenerative illnesses, more research is required.16 Chronic Pain alleviation
CBD oils' actions on brain receptors may potentially aid with pain management. Cannabis has been proven in studies to have some benefits when used following chemotherapy treatments. Other preclinical studies funded by the National Institutes of Health are looking into the effect of cannabis in treating:
● Chronic pain
● MS affliction
● Muscular ache
● Damage to the spinal cord
In the United Kingdom and Canada, Nabiximols (Sativex), a multiple sclerosis medicine produced from a mixture of TCH and CBD, has been licensed to treat MS pain. Researchers believe that the anti-inflammatory qualities of CBD in the medicine may be more important than its pain-relieving properties. To assess whether CBD should be utilized for pain treatment, clinical trials are required.15 Acne treatment
CBD's effects on immune system receptors may assist to lessen general inflammation in the body. As a result, CBD oil may be beneficial in the treatment of acne. The oil inhibited sebaceous gland activity, according to a human research published in the Journal of Clinical Investigation. Sebum, a natural oily fluid that hydrates the skin, is produced by these glands. However, too much sebum can cause acne.
It's a good idea to talk to your dermatologist before using CBD oil to treat acne. To assess the potential advantages of CBD for acne, more human research are needed.14 Sleep and Insomnia
Do you ever find yourself up late at night watching puppy videos? CBD could be useful as a sleep aid; according to Mr. MacKillop, a co-author of a paper on cannabinoids and sleep, drowsiness was one of the side effects of the Epidiolex epilepsy trials. “That could be a clue if you're seeking for novel sleep treatments,” he said.
However, he warns that the negative effects could have been caused by a drug interaction with other seizure treatments the kids were receiving. There hasn't been a randomized, placebo-controlled, double-blind trial on sleep disorders with CBD yet (the gold standard).
Anxiety improved, but not sleep, according to a recent chart study of 72 psychiatric patients treated with CBD. Dr. Scott Shannon, assistant clinical professor of psychiatry at the University of Colorado, Denver, and the lead author of the review published in The Permanente Journal, said, "Overall, we did not find that it panned out as a good treatment for sleep."
Sleep disturbances can occur for a variety of reasons, including depression. According to a review published in the Journal of Chemical Neuroanatomy, after consuming CBD, rats seemed to adapt better to stressful situations and exhibited less depressive-like behavior. In an email conversation, Sâmia Joca, a fellow at the Aarhus Institute of Advanced Studies in Denmark and an associate professor at the University of So Paulo in Brazil, stated, "Surprisingly, CBD appears to function faster than traditional antidepressants." Of course, it's difficult to detect sadness in animals, but the research Ms. Joca and her colleagues looked at revealed that mice and rats given CBD were more resilient in chronic stress situations.
However, psychologists argue CBD's effect on depression is still a hypothesis, not an evidence-based treatment, due to the lack of human clinical trials.13 Treatment for cancer
Some studies have looked into the impact of CBD in inhibiting cancer cell growth, but further research is needed. CBD, according to the National Cancer Institute (NCI), may aid with cancer symptoms and treatment adverse effects. The National Cancer Institute, on the other hand, does not completely support any kind of cannabis as a cancer treatment. CBD's ability to regulate inflammation and affect how cells reproduce makes it a viable cancer treatment. CBD inhibits the capacity of certain tumor cells to proliferate.12 Addiction
According to a 2015 review of studies published in Substance Abuse, CBD oil may help people who are addicted to drugs.
Scientists from the University of Montreal determined that CBD showed promise in treating patients addicted to opioids, cocaine, or psychostimulants based on an examination of 14 published trials (nine involving animals and five involving humans).
The effect of CBD on each addiction type, on the other hand, was frequently highly varied. In the case of opioid addiction, CBD had minimal effect in reducing withdrawal symptoms in the absence of THC. CBD, on the other hand, appeared to be beneficial in reducing drug-seeking behaviors in cocaine, methamphetamine, and other psychostimulant drug users.
CBD has also been suggested as a potential treatment for cannabis and nicotine addiction. More investigation is required.11 Pain in the Nerves
People with intractable (treatment-resistant) pain, especially those with terminal cancer, are routinely administered medical marijuana. CBD may play a role in this benefit, according to some data.
According to a 2012 study published in the Journal of Experimental Medicine, rats given with an oral dose and spinal injection of CBD exhibited less inflammation and neuropathic pain after being injected with inflammatory substances in their rear feet.
CBD is thought to lessen nerve pain via attaching to glycine receptors in the brain, which control how quickly nerve signals flow between nerve cells.
There are few human trials on CBD's usage in the treatment of chronic pain. THC is virtually always present in those that do exist, making it impossible to isolate CBD's specific effects.
According to a 2017 study published in JCI Insight, CBD oil may lower the risk of heart disease by reducing hypertension (high blood pressure) in some persons.
Nine healthy men were given either 600 mg of CBD or the equal quantity of a placebo in this trial. The researchers found that those who were given CBD had reduced blood pressure before and after being exposed to stressful stimuli (including exercise or extreme cold).
Furthermore, the stroke volume (the amount of blood left in the heart after a beating) was lowered, indicating that the heart was pumping more effectively.
The findings imply that CBD oil could be an effective supplemental therapy for persons with hypertension that is exacerbated by stress and worry. However, there is no proof that CBD oil can cure or prevent hypertension in persons who are at risk on its own. While stress has been linked to the development of high blood pressure, it cannot be the cause of hypertension.10 Depression
In preliminary studies, CBD showed promise as a treatment for depression and anxiety, and it may have fewer adverse effects in some people. Many research studies dating back to 2014 may help to explain why CBD could be effective in the treatment of depression. They claim that CBD has a beneficial interaction with the brain's serotonin receptors in the majority of trials.
Serotonin affects a variety of bodily functions, including a person's mental state and emotions of happiness or well-being. Keeping serotonin levels in check is a common therapy for persons suffering from depression. CBD appears to aid in the regulation of serotonin.9 Parkinson's disease
CBD has also been shown to be useful in treating the psychosis associated with Parkinson's disease dementia (PDD). So far, patients are tolerant of low dosages of CBD oil and report beneficial results.
Numerous more studies echo CBD’s benefits:
– Researchers in Brazil have earlier highlighted “Our findings hint to a possible benefit of CBD in improving quality of life measures in PD patients.”
– Researchers from the University of Colorado's Department of Neuroscience and Behavior concluded that "preliminary data suggest that CBD may be effective, safe, and well tolerated for the treatment of psychosis in Parkinson's disease."
– Another Colorado study found that "cannabis was rarely used in our population but users reported high efficacy, primarily for nonmotor symptoms."
These more recent revelations follow federally funded preclinical studies published in 1998 that found CBD and THC to have strong antioxidant and neuroprotective properties, especially in the treatment of "neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and HIV dementia." Cannabinoids as antioxidants and neuroprotectants were patented by the US government as a result of these encouraging findings. Furthermore, as a growing number of jurisdictions legalize cannabis for medicinal and even recreational uses, THC and CBD products are becoming more widespread. (See below for more information on CBD that has been legalized.)
Epidiolex, the first FDA-approved CBD medicine, was approved in June 2018 to treat two uncommon kinds of epilepsy. Epidiolex may have a future in treating other disorders, such as Parkinson's, according to a study published in 2020, which found that most Parkinson's patients improved their motor function after taking the medicine. Nighttime sleep, as well as emotional and behavioral concerns, improved dramatically.8 Glaucoma
Based on the chemical makeup and specific strain of the plant, clinical and basic scientific research have revealed significant variances in the IOP-lowering effects of cannabis. Cairns and colleagues discovered that tetrahydrocannabinol (THC), one of the main components of cannabis, decreases IOP through binding to the CB1 receptor found in ciliary epithelium and trabecular meshwork cells. However, another key component of cannabis, cannabidiol (CBD), has the opposite impact on IOP and may be harmful to people who have glaucoma.
Six individuals with ocular hypertension or mild primary open-angle glaucoma were studied in a randomized, double-masked, placebo-controlled crossover research by Tomida and colleagues.
3 Patients were randomly randomized to therapy with sublingual THC, lower-dose (20 mg) sublingual CBD, higher-dose (40 mg) sublingual CBD, or placebo after washing off their regular topical IOP-lowering regimen. Patients who received THC experienced a modest decrease in IOP two hours after treatment, compared to placebo, whereas those who received the greater dose of CBD experienced a slight increase in IOP.
Miller and colleagues conducted a basic science investigation in which living mice were given topical THC and CBD and the results were positive.
CB1 knockout mice were also used to further investigate the effects of these drugs. Topical THC was observed to reduce IOP 8 hours after application, however topical CBD increased IOP significantly. This effect was not found in CB1 knockout animals, implying that CBD may have a THC antagonistic action at this receptor. THC and CBD were applied simultaneously to mice and had no effect on IOP, likely because the effects of each agent were cancelled out.
Cannabis is legal for therapeutic use in Canada. Medical cannabis is also approved for the medical treatment of cancer, irritable bowel syndrome, and a variety of pain diseases, in addition to glaucoma. THC and CBD levels differ amongst products, and studies have revealed that not all cannabis strains have the same benefits. As previously stated, strains with higher THC concentration are likely to have lower IOP, whilst strains with more CBD content are likely to have higher IOP. As a result, eye care physicians should warn patients who want to use medical cannabis to treat their glaucoma that products with a high CBD content may have a negative impact on their disease process.
The majority of investigations using medical cannabis for glaucoma treatment have revealed a short duration of activity and accompanying systemic symptoms such as euphoria and hypotension. Because of these concerns, several prestigious medical societies have concluded that the risks of cannabis consumption outweigh any potential benefits. Furthermore, in their current condition, medicinal, laser, and surgical IOP-lowering therapies are more effective than cannabis-derived therapies. 5
However, research by Tomida et al suggests that the inconsistent results of previous studies on the effect of cannabis on IOP could be due to the use of different strains with different concentrations of THC and CBD. To effectively assess medicinal potential, future studies examining cannabis and IOP lowering should identify the strain and THC/CBD makeup.7 Stroke
The side effects of a stroke are caused by damaged neurons.
When neurons lack the oxygen and nutrients they require, they become damaged and may die, leaving us with long-term neurological consequences. Working on the overall health of the neurons is one of the most important aspects of assisting stroke victims.
CBD is very beneficial to neuron health. CBD promotes neuron health by assisting calcium ion handling (which is required for nerves to transmit electrical impulses) and neuron metabolism (how the neurons generate energy to survive).6 Irritable Bowel (IBS)
According to the National Centers for Complementary and Integrative Health, some evidence suggests that CBD could have modest benefits for inflammatory bowel disease. However, they note that more studies are needed to examine using CBD for IBS.
While there are limited studies looking at this, other research investigating the substance’s properties indicates that it may be beneficial for the condition.
A review in Molecules notes how CBD may be useful for treating pain and inflammation, properties that could help remedy IBS. A 2020 review also concludes that CBD could, in some cases, have benefits for relieving chronic pain and reducing inflammation.5 Bipolar Disorder
In the United States, bipolar disorder is occasionally referred to as manic-depressive disorder, a term that is now considered archaic. Major changes in mood and energy levels characterize this illness.
Many persons with bipolar disorder have depressed and manic episodes, while the severity of these episodes varies depending on the kind of bipolar disease.
According to studies, up to 4.4 percent of adults in the United States suffer from bipolar disorder at some point in their lives.
CBD is a health supplement that many people use to improve their mental and physical wellbeing. Is there, however, any proof that CBD can help with bipolar disorder? Here's everything you need to know about it.
A 2008 case study is one of the few studies that specifically looks at the effects of CBD on bipolar disorder in particular. This study looked at two bipolar disorder I patients who were experiencing manic episodes and were receiving inpatient treatment. CBD did not appear to be useful for manic episodes, according to the findings. Neither participant, however, appeared to have any negative side effects.
It's worth mentioning that only two persons were studied, and only during manic episodes.
The study mentioned above was published almost a decade ago. There haven't been any fresh studies on the effects of CBD on bipolar disorder.
More research, particularly on the effects of CBD during a depressive episode, is required. Researchers have advised that CBD's effects on depressive episodes be explored because some (limited) research suggests CBD may have anti-depressant benefits.4 Anorexia
Eating disorders are serious illnesses caused by uncontrollable eating habits that have a harmful influence on one's health, emotions, and capacity to perform in important areas of life.
Anorexia nervosa, binge eating disorder (BED), and bulimia nervosa are three of the most frequent eating disorders.
The majority of eating disorders are characterized by an excessive concern on weight, body form, and food, which leads to harmful eating practices. These habits can have a big impact on the body's ability to get enough nourishment.
Eating disorders can harm the heart, digestive system, bones, teeth, and mouth, among other organs, as well as cause other problems.
Anxiety, depression, and obsessive-compulsive disorder (OCD) are just a few of the mental health illnesses that frequently occur alongside eating disorders.
A study of almost 2,400 people who were hospitalized for an eating issue discovered that 94 percent of them also had a mood disorder.
The body is denied the vital nutrition it need to operate normally in anorexia's cycle of self-starvation, leading in catastrophic medical repercussions. CBD may assist to enhance anorexia-related mood by lowering anxiety. CBD has therapeutic potential as an anti-anxiety and antidepressant-like substance, according to a study published in CNS and Neurological Disorders – Drug Targets.
Researchers from a 2018 study published in the Frontiers in Immunology Journal found comparable results, indicating that CBD could be used to treat depression.
The findings of a study back up beliefs that prolonged anxiety or stress disrupts brain networks that regulate hunger, perhaps leading to eating disorders or obesity.
As a result, lowering stress levels may aid in improving mood and encouraging good eating habits.3 Allergies & Asthma
Asthma is a chronic lung condition caused by underlying airway inflammation, with flare-ups causing wheezing, coughing, and other breathing problems. Can CBD oil actually help asthma, despite its probable role in airway inflammation?
CBD is gaining popularity as a result of its anti-inflammatory and antioxidant properties. It may also provide stronger neuroprotective advantages than vitamins C and E, according to some research.
CBD oil has been shown to reduce airway hyperresponsiveness, making your lungs less sensitive to asthma triggers. As a result, there are fewer flare-ups and symptoms like coughing. CBD reduced airway inflammation and hyperresponsiveness in mice with allergic asthma, according to a 2019 study. More research in humans is needed, however, to see if CBD oil is an effective treatment for allergy-induced asthma.2 High blood pressure
CBD may help to decrease blood pressure, according to some studies.
People with high blood pressure may be prescribed drugs by their doctors. It is critical to contact a doctor if a person is taking blood pressure medicine and using CBD products.
What is the conclusion of the research?
According to certain studies, CBD-infused products may aid in the reduction of blood pressure.
CBD may have vasodilatory benefits in human and rat arteries, according to a 2020 study. CBD may increase a person's blood flow by widening their blood vessels, according to the authors.
A 2017 study also looked at the effects of a single dose of CBD oil on healthy people. It decreased blood pressure in both people who were at rest and those who were under stress, according to the authors.
Oils, candies, tinctures or drops, and capsules are among the CBD products that may be beneficial to people with hypertension. They come in two varieties: full-spectrum and broad-spectrum.
Natural cannabis plant extracts and up to 0.3 percent THC make up full-spectrum products. Broad-spectrum CBD products contain a variety of cannabis plant components but do not contain THC. However, these may include traces of THC in some cases. Before purchasing a product, it is critical to read the label. THC concentrations of up to 0.3 percent have been found in some products.1 Muscle Spasms / Multiple Sclerosis
Most of the millions of people living with multiple sclerosis have to deal with stiff, hurting, cramping muscles on a daily basis. Many of the people who have had spinal cord injuries experience the same symptoms, which include discomfort, limited mobility, and a lack of sleep. Although a variety of traditional drugs can help these individuals feel better, they rarely provide complete relief. Weakness, sleepiness, and other side symptoms are common, and some patients find them intolerable.
Given this perspective, it's easy to see why some patients suffering from multiple sclerosis and spinal cord injuries have turned to marijuana for comfort. Several of these patients reported that smoking marijuana reduced their muscle spasms. Some people stated they liked the medicine because it helped them sleep or alleviated nausea. Similarly, 21 of 43 respondents in a 1982 survey of people with spinal cord injuries said marijuana helped them with muscle spasticity1 (a condition in which muscles tense reflexively and resist stretching), and nearly every participant in a 1997 survey of 112 regular marijuana users with multiple sclerosis said the drug helped them with pain and spasticity. This isn't to suggest that most persons with multiple sclerosis benefit from marijuana; rather, it's to say that marijuana users do.
A wide range of disorders have been linked to the endocannabinoid system and cannabinoid-based therapy. Several studies have suggested that cannabinoids and endocannabinoids may have a role in the etiology and treatment of multiple sclerosis (MS). The main findings reported in the literature about the usefulness of cannabis therapies in the management and treatment of MS are highlighted in this study. Cannabinoids appear to have therapeutic benefits on MS symptoms such as stiffness and pain, according to a growing body of data. The current treatments for MS symptoms as well as the most recent clinical research based on cannabis therapy, albeit long-term studies are needed to determine whether cannabinoids have a role in MS that goes beyond symptom relief.